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Image Search Results
Journal: International Journal of Biological Sciences
Article Title: ADAR1 protects pulmonary macrophages from sepsis-induced pyroptosis and lung injury through miR-21/A20 signaling
doi: 10.7150/ijbs.86424
Figure Lengend Snippet: ADAR1 alleviates bacterial burden in septic mice, increases the CD4 + /CD8 + ratio in peripheral blood, and promotes immune restoration. N = 6 in each group. (A) A comprehensive analysis was conducted on peripheral blood samples from mice in the sham, CLP, and CLP+OE-A groups to compare and evaluate the levels of leukocytes, lymphocytes, and neutrophils. (B) Flow cytometry was used to analyse the effect of ADAR1 on the CD4 + /CD8 + ratio in mouse peripheral blood. (C) The levels of bacteria in blood and lung tissues after sham, CLP, and CLP+OE-A interventions using bacterial culture. The injection of the ADAR1 virus reduced the bacterial burden in the blood and lung compared to that in the CLP group. Data are shown as the mean ± SD. * P < 0.05, ** P < 0.01, *** P < 0.001 versus CLP.
Article Snippet: For PBMC isolation, blood samples were added to a Lymphocyte Separation Tube for
Techniques: Flow Cytometry, Bacteria, Injection, Virus